Ophthalmic Research

Research Interests

  • Autoregulation of retinal blood flow (myogenic and flow-induced responses)
    Metabolic vasoregulation in the retina
  • Vascular dysregulation in disease states (i.e., glaucoma, diabetes, hypertension, inflammation, atherosclerosis/hyperlipidemia)
  • Ischemia-reperfusion injury
  • Gene transfection in retinal vascular diseases
  • Retinal and choroidal angiogenesis

Figure 1A
Figure 1A

Figure 1B
Figure 1B
Figure 1 – (1A and 1B) Porcine retina as viewed with a dissecting microscope. Note the optic disc and peripapillary retina (left) and the parallel and branching arrangement of the retinal arterioles and venules (right) which is similar to the human retina.

Figure 2A
Figure 2A

Figure 2B
Figure 2B
Figure 2 – (2A and 2B) An isolated retinal arteriole (left) is cannulated with glass micropipettes and secured with ophthalmic sutures (viewed under a dissecting microscope, x20). The isolated vessel is transferred to the stage of an inverted microscope (right) and allowed to develop spontaneous (basal) tone at 55 cmH2O intraluminal pressure and 37 C bath temperature (inverted microscope, x20).

Figure 3
Figure 3

Dilation of an isolated retinal arteriole to endothelium-dependent vasodilator bradykinin.

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