Abiraterone (By mouth)
Abiraterone Acetate (a-bir-A-ter-one AS-e-tate)
Treats metastatic castration-resistant prostate cancer. This medicine is used in combination with prednisone.
ZytigaThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to abiraterone. Women who are pregnant or able to become pregnant should not use this medicine.
How to Use This Medicine:
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- Take this medicine on an empty stomach. Do not eat 2 hours before or 1 hour after you take this medicine.
- Swallow the tablet whole with water. Do not break, crush, or chew it.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:
- If you missed a dose of this medicine, take your normal dose on the following day. If more than one daily dose is missed, call your doctor right away.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use dextromethorphan (Benylin), enzalutamide (Xtandi), paclitaxel (Taxol), repaglinide (Prandin), rosiglitazone (Avandia), or thioridazine (Mellaril). Tell your doctor if you also use medicine to treat HIV/AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Norvir), medicine to treat an infection (such as clarithromycin, itraconazole, ketoconazole, telithromycin, voriconazole, Nizoral), medicine to treat tuberculosis (such as rifabutin, rifampin, rifapentine, Mycobutin, Priftin, Rifadin, Rimactane), medicine to treat seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin, Tegretol), or medicine to treat depression (such as nefazodone, Serzone).
- Tell your doctor if you use another steroid medicine, such as dexamethasone or Medrol.
Warnings While Using This Medicine:
- Pregnant women or women who may become pregnant should not handle or touch the tablets without protection. This medicine may cause birth defects if the father is using it when his partner becomes pregnant. You must use a condom and another effective method of birth control during treatment and for 1 week after the last dose. Tell your doctor right away if a pregnancy occurs while you are using this medicine.
- Make sure your doctor knows if you have had a recent heart attack or if you have heart or blood vessel disease, heart failure, heart rhythm problems, high blood pressure, or low potassium in the blood. Tell your doctor if you have liver disease or a history of adrenal problems.
- Do not stop using this medicine or prednisone without asking your doctor, even for a short time.
- Talk to your doctor if you have more than one of these symptoms while you are using this medicine: darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, nausea, skin rash, or vomiting. These may be symptoms of adrenal problems.
- Check with your doctor right away if you have upper stomach pain, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.
- This medicine may increase your risk for fractures. Call your doctor right away if you have pain or swelling in your arms or legs, even if you have not been injured.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
- You will need to have your blood pressure measured before you begin to use this medicine and while you are using it. Talk to your doctor if you have questions.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain
- Dark urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
- Dry mouth, increased thirst, muscle cramps
- Fast, slow, pounding, or uneven heartbeat
- Rapid weight gain, swelling in your hands, ankles, or feet
- Unusual tiredness or weakness
If you notice these less serious side effects, talk with your doctor:
- Change in how much or how often you urinate, difficult or painful urination
- Cough, runny or stuffy nose, sore throat
- Diarrhea or stomach upset
- Joint pain or swelling
- Muscle pain
- Warmth or redness in your face, neck, arms, or upper chest
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
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