Pazopanib (By mouth)
Treats late-stage kidney cancer and advanced soft tissue sarcoma.
VotrientThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to pazopanib or if you are pregnant.
How to Use This Medicine:
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- It is best to take this medicine on an empty stomach. Take this medicine at least 1 hour before or 2 hours after a meal.
- Swallow the tablet whole. Do not crush, break, or chew it.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to take your medicine and it is less than 12 hours until your next dose, skip that dose and take your next dose at the normal time. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use clarithromycin (Biaxin), ketoconazole (Nizoral), rifampin (Rifadin, Rimactane), ritonavir (Norvir), simvastatin (Zocor), or medicine for heart rhythm problems (such as amiodarone, disopyramide, dofetilide, flecainide, Cordarone, Norpace, Tambocor, Tikosyn).
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- Your unborn baby could be harmed if you use this medicine while you are pregnant. Use an effective form of birth control to keep from getting pregnant. Tell your doctor right away if you think you have become pregnant while using the medicine.
- Make sure your doctor knows if you are breastfeeding or if you have kidney disease, liver disease (including Gilbert syndrome), heart disease, high blood pressure, heart rhythm problems (such as QT prolongation), stomach or bowel problems, an underactive thyroid, or a history of severe chest pain, heart attack, or stroke.
- Tell your doctor if you have had any bleeding problems in the last 6 months, including bleeding in your digestive system. Some possible symptoms are coughing up blood, vomiting blood or material that looks like coffee grounds, or black or bloody stools.
- Check with your doctor right away if you have any symptoms of liver problems, such as dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, or yellow skin or eyes.
- This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or uneven heartbeats.
- Check with your doctor right away if you are rapidly gaining weight or have chest pain or discomfort, extreme tiredness or weakness, trouble breathing, irregular heartbeat, or swelling. These may be symptoms of heart problems.
- Check with your doctor right away if you have severe abdominal or stomach burning, cramps, or pains, bloody or tarry stools, trouble breathing, heartburn, indigestion, nausea, or vomiting of material that looks like coffee grounds. These could be symptoms of a serious bowel problem.
- This medicine may increase your chance of having a brain condition called reversible posterior leukoencephalopathy syndrome (RPLS). Check with your doctor right away if you have headaches, seizures, extreme drowsiness, confusion, or problems with vision while you are using this medicine.
- This medicine may affect the way your body heals from cuts and wounds. Make sure any doctor who treats you knows that you are using this medicine. You may need to stop using this medicine at least 7 days before you have surgery.
- This medicine may increase your chance of bleeding. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when you use sharp objects, including razors and fingernail clippers.
- Call your doctor right away if you start to have a cough that won't go away, weight loss, night sweats, fever, chills, a runny or stuffy nose, headache, blurred vision, or feeling generally ill. These may be signs that you have an infection.
- Cancer medicines can cause diarrhea, nausea, or vomiting in most people, sometimes even after they receive medicine to prevent it. Ask your doctor or nurse about other ways to control these side effects.
- You will need to have your blood pressure measured before you start this medicine and while you are using it. If you notice any change to your recommended blood pressure, call your doctor right away.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Bloody or black, tarry stools
- Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing
- Cloudy urine
- Fast, pounding, or uneven heartbeat
- Fever, chills, cough, sore throat, and body aches
- Lightheadedness, dizziness, fainting
- Nausea, vomiting, loss of appetite, dark-colored urine or pale stools, or pain in your upper stomach
- Numbness or weakness on one side of your body
- Pain in your lower leg (calf)
- Rapid weight gain, swelling in your hands, ankles, or feet
- Stomach pain
- Sudden or severe headache, problems with vision, speech, or walking
- Unusual bleeding, bruising, or weakness
- Vomiting of blood or material that looks like coffee grounds
- Yellow skin or eyes
If you notice these less serious side effects, talk with your doctor:
- Change in skin or hair color, hair loss
- Change or loss of taste
- Mild headache
- Mild nausea, vomiting, diarrhea
- Muscle or joint pain
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
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