Tapentadol (By mouth)
Treats moderate to severe pain. Also treats nerve pain caused by diabetes. This medicine is a narcotic pain reliever.
Nucynta, Nucynta ERThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:Do not use this medicine if you have had an allergic reaction to tapentadol, or if you have used an MAO inhibitor (MAOI) such as isocarboxazid, phenelzine, selegiline, tranylcypromine, Eldepryl, Marplan, Nardil, or Parnate within the past 14 days. Do not use this medicine if you have serious asthma or other breathing problems, or if you have paralytic ileus (blocked bowel).
How to Use This Medicine:
Tablet, Long Acting Tablet
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- Swallow the extended-release tablet whole. Do not crush, break, or chew it. Take the tablets 1 at a time, if your doctor has told you to take more than 1. Swallow the tablet with plenty of water to make sure it goes all the way to your stomach.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed. Flush all unneeded medicine down the toilet. This medicine is one of only a few medicines that should be disposed of this way.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using other narcotic pain medicine (such as buprenorphine, butorphanol, nalbuphine, pentazocine, tramadol, Ultram), medicine for depression (such as amitriptyline, citalopram, fluoxetine, mirtazapine, nortriptyline, sertraline, trazodone, Cymbalta, Effexor, Elavil, Lexapro, Pristiq), or medicine to treat migraine headaches (such as eletriptan, frovatriptan, rizatriptan, sumatriptan, zolmitriptan, Frova, Maxalt, Relpax, Zomig).
- Tell your doctor if you are using a phenothiazine medicine, such as prochlorperazine, promethazine, Compazine, Mellaril, Phenergan, Thorazine, or Trilafon. These medicines may be used to treat severe vomiting, coughing, psychiatric problems, or other conditions.
- Do not drink alcohol while you are using this medicine.
- Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
Warnings While Using This Medicine:
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, gallbladder problems, pancreas problems, or problems with urination. Tell your doctor if you have a history of head injury, brain tumor, seizures, depression, or mental problems. Also tell your doctor if you have a history of alcohol or drug abuse.
- This medicine may slow down your breathing and cause you to not get enough oxygen. Make sure your doctor knows if you already have a breathing or lung problem, such as chronic obstructive pulmonary disease (COPD) or asthma. This effect on breathing is more likely to happen when you first start this medicine or when your dose is increased. Tell your doctor if you have trouble breathing, slow or shallow breathing, or any other changes.
- Do not take more of this medicine or take it more often than your doctor tells you to. This can be life-threatening, especially in children. Symptoms of an overdose include extreme dizziness or weakness, trouble breathing, slow heartbeat, seizure, and cold, clammy skin.
- This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
- This medicine may make you dizzy, drowsy, or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel lightheaded or dizzy.
- Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
- This medicine may cause a serious condition called serotonin syndrome when taken with certain medicines. Make sure any doctor or dentist who treats you knows that you are using this medicine.
- This medicine may cause constipation. This is more common if you use it for a long time. Ask your doctor if you should also use a laxative to prevent and treat constipation.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Extreme weakness or sleepiness, cold or clammy skin
- Fast, slow, or uneven heartbeat
- Fainting, lightheadedness, dizziness
- Trouble breathing, shallow breathing
If you notice these less serious side effects, talk with your doctor:
- Dry mouth
- Nausea, vomiting, constipation
- Mild sleepiness or tiredness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
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