Hyperparathyroidism is a condition in which the parathyroid glands, located in the neck, secrete too much parathyroid hormone (PTH). Parathyroid hormone regulates the amount of calcium and phosphorus (minerals necessary for strong bones and teeth) in the body, by controlling how much calcium is taken from bones, absorbed in the intestines, and lost in urine. When too much parathyroid hormone is secreted, levels of calcium in the blood and urine rise, and bones may lose calcium, leading to osteoporosis.

In about half of the cases of primary hyperparathyroidism, the patient has either vague symptoms or no symptoms at all. The condition is often diagnosed through routine blood tests that show high levels of calcium. When symptoms do occur, they are generally due to persistently high levels of calcium and may include:

• Joint pain
• Bone loss leading to osteoporosis
• Muscle weakness
• Abdominal discomfort
• Nausea and vomiting
• Constipation
• Lack of appetite
• Kidney stones
• Excessive thirst
• Excessive urination
• Anxiety
• Memory loss
• Fatigue
• Irregular heart beats or other heart conditions

In most cases, the cause of hyperparathyroidism is not known. It may develop as a result of one of the following conditions:

• Benign tumors in the parathyroid glands
• Parathyroid hyperplasia (excessive growth of normal parathyroid cells)
• Parathyroid cancer (rare)
• Certain endocrine disorders, such as Type I and II multiple endocrine neoplasia (MEN) syndromes (rare)

The following conditions or characteristics put you at higher risk for developing primary hyperparathyroidism:

• Age: risk increases as you get older, reaching a peak between 50 -60 years (but the disease can also affect children).
• Gender: most cases occur in women (74%).
• Inherited endocrine problems (MEN syndromes)
• Previous neck irradiation
• Depression
• Obesity

Hyperparathyroidism is diagnosed through blood tests that show high levels of calcium and parathyroid hormone. About half the time, health care providers discover primary hyperparathyroidism from a routine blood test. If your doctor suspects primary hyperparathyroidism, the doctor will do a physical examination and ask about symptoms of abdominal pain and constipation, depression, anxiety, memory loss, muscle weakness, and urinary problems. The health care provider may take a sample of your urine to test for kidney problems caused by excess calcium, and have you take a bone density scan to check bone health. An ultrasound of the neck may be performed to see if the parathyroid glands are enlarged. A computed tomography (CT) scan or magnetic resonance imaging (MRI) may be used to check for a tumor.

Prevention

There is no known way to prevent primary hyperparathyroidism. However, people who are at risk should avoid dehydration.

Treatment Plan

Surgery to remove one or more of the parathyroid glands is very successful in treating primary hyperparathyroidism. If a person does not show any signs or symptoms of the disease, and has only mildly elevated calcium levels, they may not need immediate treatment (but they will need to be monitored for calcium blood levels and bone density to watch for any changes in their condition).

Drug Therapies

Surgery is the primary treatment. However, under certain circumstances, your health care provider may prescribe the following medications:

• A specific type of diuretic, along with intravenous fluids, to lower levels of calcium in the blood while the person is awaiting surgery
• Calcitonin by injection to build bone density
• Bisphosphonates, such as tiludronate and alendronate, after surgery to lower calcium levels
• Estrogens, such as Raloxifene, to increase bone density

Surgical and Other Procedures

Parathyroidectomy involves removal of one or more of the four parathyroid glands.

Complementary and Alternative Therapies

Hyperparathyroidism should never be treated by alternative medicine alone. Some CAM therapies may support conventional treatment. Keep all of your health care providers informed about any CAM therapies you are considering using.

Nutrition and Supplements

Following these nutritional tips may help reduce symptoms of hyperparathyroidism. Do not take these supplements without your health care provider's supervision:

• Eliminate all potential food allergens, including dairy, wheat (gluten), soy, corn, preservatives, and food additives. Your health care provider may want to test for food sensitivities.
• Eat calcium-rich foods, including beans, almonds, and dark green leafy vegetables (such as spinach and kale).
• Avoid refined foods, such as white breads, pastas, and sugar.
• Eat fewer red meats and more lean meats, cold water fish, tofu (soy), or beans for protein.
• Use healthy cooking oils, such as olive oil or vegetable oil.
• Reduce or eliminate trans-fatty acids, found in commercially baked goods such as cookies, crackers, cakes, and donuts. They are also found in French fries, onion rings, processed foods, and margarine.
• Limit carbonated beverages. They are high in phosphates, which can leach calcium from your bones.
• Avoid coffee and other stimulants, alcohol, and tobacco.
• Drink 6 - 8 glasses of filtered water daily.
• Exercise moderately at least 30 minutes daily, 5 days a week.

You may address nutritional deficiencies with the following supplements:

• A multivitamin daily, containing the antioxidant vitamins A, C, E, the B-complex vitamins and trace minerals, such as magnesium, calcium, zinc, and selenium.
• Calcium citrate, 500 - 1,000 mg daily, for bone support.
• Vitamin D, 400 IU daily, for bone support and immunity.
• Ipriflavone (soy isoflavones) standardized extract, 200 mg 3 times a day, for bone loss. Because hyperparathyroidism may lead to osteoporosis, taking ipriflavone may help treat this cause of bone loss. Ipriflavone can lower white blood cell counts and has the potential to interact with a variety of medications; speak with your physician.
• Omega-3 fatty acids, such as fish oils, 1 - 2 capsules or 1 - 2 tablespoonfuls of oil daily, to help decrease inflammation and support healthy metabolism. Omega-3 fatty acids can have a blood-thinning effect and may increase the effect of blood-thinning medications, such as warfarin (Coumadin) and aspirin.
• Foods rich in calcium include:
  • Almonds
  • Legumes
  • Dark leafy greens
  • Blackstrap molasses
  • Oats
  • Sardines
  • Tahini
  • Prunes
  • Apricots

Your doctor may recommend you take calcium with a glass of orange juice -- some forms of calcium are better absorbed in an acidic environment. You can also add acid to your diet by squeezing lemon juice over leafy greens.

Herbs

Herbs are generally available as standardized dried extracts (pills, capsules, or tablets), teas, or tinctures/liquid extracts (alcohol extraction, unless otherwise noted). Mix liquid extracts with favorite beverage. Dose for teas is 1 - 2 heaping teaspoonfuls/cup water steeped for 10 - 15 minutes (roots need longer).

The following herbs are sometimes used to counter the bone loss that can occur from hyperparathyroidism, though scientific studies are lacking. Talk to your health care provider before taking any herbs if you have hyperparathyroidism.

• Chaste tree (Vitex agnus castus) standardized extract, 20 - 40 mg daily before breakfast, for support of the parathyroid gland. Chaste tree extract has many possible drug interactions and can have hormone-like effects in the body. People with a history of hormone-related conditions shouldbeparticularly cautious. Speak with your physician.
• Dandelion (Taraxacum officinale) leaf tincture, 5 - 10 mL 2 - 3 times a day, for its high mineral content. You can also prepare teas from the leaf. Certain drugs can interact with Dandelion, including lithium and some antibiotics. Speak with your physician. People with Ragweed allergies may also have an allergic reaction to Dandelion.

Homeopathy

Although few studies have examined the effectiveness of specific homeopathic therapies, professional homeopaths may consider the following remedies for the treatment of hyperparathyroidism based on their knowledge and experience. Before prescribing a remedy, homeopaths take into account a person's constitutional type -- your physical, emotional, and psychological makeup. An experienced homeopath assesses all of these factors when determining the most appropriate treatment for each individual.

• Calcarea carbonica (calcium carbonate)
• Calcarea phosphorica (calcium phosphate)

The prognosis is excellent for persons with primary hyperparathyroidism who have no symptoms, as well as those who have surgery to remove one or more parathyroid glands, with cure rates of 94 - 96%. Minimally invasive surgery is associated with improvements in the cure rate (99.4%). Possible complications include skeletal damage, urinary tract infections, kidney damage or kidney stones, peptic ulcers, inflammation of the pancreas, high blood pressure, nervous system disorders, and rare complications from surgery. Various cardiovascular conditions are also associated with hyperparathyroidism.

If you have surgery, your doctor will check your blood calcium levels for several months to be sure that the levels remain stable. If you do not have surgery, your calcium levels will need to be checked over a longer period of time, and your checkups will include a careful assessment of your bones and kidneys.

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