Allogeneic Blood Stem-Cell Transplant

After your initial induction therapy, you generally receive consolidation therapy. However, in some cases, your physician may suggest you consider receiving blood stem-cell transplant in place of consolidation therapy.

Blood stem-cell transplant is a procedure to replace your leukemic bone marrow with healthy bone marrow stem cells. An allogeneic transplant (ALLO) involves removing bone marrow from a matched donor. Allo means “other.”

The Process of an ALLO Transplant

  • Blood stem cells are removed from your body and discarded.
  • While hospitalized, you then receive intensive, high-dose chemotherapy, killing leukemic cells.
  • Healthy stem cells are then transplanted from a matched donor.
  • You will be in the hospital several weeks.
  • It’s a high-risk procedure appropriate for only certain patients.

Factors That Impact Whether You Are a Candidate for ALLO Transplant

  • The likelihood chemotherapy alone will cure your leukemia
  • The type of gene changes you have
  • The availability of a healthy donor (e.g., brother, sister; member of Bone Marrow Registry)
  • Your overall health
    • Your heart health
    • Your kidney health
  • Whether you can tolerate the intense chemotherapy
  • Your personal preference

If we can get the disease under control with induction therapy, we can then come back and do the ALLO transplant as a way of ultimately controlling the disease.

Mark H. Holguin, MD, Hematology/Oncology; Chief – Section of Hematology

Scott & White does not offer allogeneic blood stem-cell transplants. (We do offer autologous transplants, but those have not proven helpful in most cases of leukemia.)

All allogeneic blood stem-cell transplants are referred to one of our accredited partners in the state.

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