Multiple Endocrine Neoplasia Type 2 Treatment Options

Generally, surgery is the first line of treatment for MEN2 tumors; however, in some cases, the kind of treatment you receive depends on the location of your tumor. Sometimes, careful watching is the recommended treatment, as many endocrine tumors associated with MEN2 are noncancerous (benign).

Following active treatment, your oncology team will work with you to create the most appropriate follow-up care plan.

Medullary Carcinoma of the Thyroid (MTC)

Your physician will generally recommend the surgical removal of the entire thyroid gland and the surrounding lymph nodes. You will need thyroid hormone replacement therapy.

Pheochromocytoma

Your physician will generally recommend the surgical removal of pheochromocytomas. In many cases, this surgery can be performed laparoscopically or with other minimally invasive surgical techniques.

Parathyroid Problems

You will be monitored regularly for hyperparathyroidism, including biochemical screening for parathyroid adenomas (noncancerous tumors) and hyperplasia. Surgery (parathyroidectomy) is the preferred treatment for hyperparathyroidism, and your surgeon will help determine the best timing for treatment of hyperparathyroidism.

RET Gene

If a child is known to carry the RET gene change, we recommend the surgical removal of the thyroid at approximately age 5 before the cancerous changes begin in the thyroid.

In the cases of MEN2B, we recommend the surgical removal of the thyroid in the first year of life or as soon as the diagnosis is made.


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