Multiple Endocrine Neoplasia (MEN) Type 2 Screening Guidelines and Diagnostic Services

MEN Type 2 Screening Guidelines

If a family member has a history of MEN2, the Scott & White Cancer Genetics Clinic and your Integrated Care Team encourage careful watching over the course of your lifetime.

Here are our management and early screening recommendations for MEN2:

  • Medullary thyroid carcinoma (MTC)
    • Prophylactic thyroidectomy (surgical removal of the thyroid) for patients at approximately 5 years of age for MEN2A
    • Monitor for residual or recurrent MTC after thyroidectomy
    • Annual calcitonin stimulation test
  • Pheochromocytomas (PHEO)
    • Initial screen at diagnosis
    • Annual biochemical screen 
    • CT or MRI if abnormal
  • Parathyroid problems
    • Annual testing with calcium and parathyroid hormone (PTH) levels in bloodstream
  • MEN2B
    • Prophylactic thyroidectomy (the surgical removal of the thyroid) for patients as early as the first year of life or as soon as the diagnosis is made

To diagnose MEN2, your physician will order genetic testing to look for changes in the RET gene. Your physician may order imaging and laboratory tests to determine which hormones are being overproduced.

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MEN Type 2 Diagnostic Services

If you have symptoms that suggest you may have MEN2, your physician may order one or more of the following tests to confirm that you have MEN2.

Imaging Tests

Laboratory Tests

Blood and Tumor Marker Tests

Your physician may order one or more blood tests during and after your treatment. Your physician may also order tumor marker tests. A tumor marker is a substance that may be found in a tumor or released from a tumor into your blood or other body fluids. A high level of a tumor marker may note the presence of a certain type of cancer.

Your physician may order the following blood and tumor marker tests:

  • Calcitonin. This tumor marker test is useful in identifying the presence of medullary thyroid cancer (MTC); patients with MTC often have high levels of calcitonin
  • Blood calcium. Elevated levels may indicate tumors in the parathyroid
  • Parathyroid hormone. Elevated levels may indicate tumors in the parathyroid
  • Urine catecholamines. Elevated levels may indicate tumors in the adrenal glands
  • Urine metanephrine. Elevated levels may indicate tumors in the adrenal glands

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Scott & White Cancer Genetics Services

If you have a family member with MEN2 or were diagnosed with two or more endocrine tumors, your physician will recommend that you have genetic counseling to determine whether you are a good candidate for MEN2 genetic testing.

Genetic counseling is available here at the Scott & White Cancer Genetics Clinic to help identify individuals and families who carry the RET gene and are at an increased risk to develop MEN2.

The Scott & White Cancer Genetics Clinic is located at 3 South, Brindley Circles, Rooms 341 and 342 on the Scott & White campus in Temple. For more information, please call 254-724-3379.

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