Rotavirus Vaccine

What You Need to Know

WHAT IS ROTAVIRUS?

Rotavirus is a virus that causes diarrhea (sometimes severe), mostly in infants and young children. It is often accompanied by vomiting and fever, and can lead to dehydration.

Rotavirus is not the only cause of diarrhea, but it is one of the most serious. Before a vaccine was available, rotavirus was responsible for more than 400,000 doctor visits, more than 200,000 Emergency Department visits, 55,000 to 70,000 hospitalizations, and 20 to 60 deaths in the United States each year. Almost all children in the U.S. were infected with rotavirus before their 5th birthday.

ROTAVIRUS VACCINE

  • Better hygiene and sanitation have not reduced rotavirus diarrhea very much in the United States. The best way to protect your infant from rotavirus disease is with rotavirus vaccine.

  • Rotavirus vaccine is an oral (swallowed) vaccine, not a shot.

  • Rotavirus vaccine will not prevent diarrhea or vomiting caused by other germs, but it is very good at preventing diarrhea and vomiting caused by rotavirus. Most infants who get the vaccine will not get rotavirus diarrhea at all, and almost all of them will be protected from severe rotavirus diarrhea.

  • Rotavirus vaccine has been used since 2006 in the United States. By 2010, it had reduced the number of infants and young children needing Emergency Department care or hospitalization for rotavirus disease by about 85%.

WHO SHOULD GET ROTAVIRUS VACCINE AND WHEN?

There are 2 brands of rotavirus vaccine. Both vaccines are effective.

Your infant could get either 2 or 3 doses, depending on which brand is used. Your caregiver can tell you which brand your infant will be getting.

  • The doses are recommended at these ages:

  • First Dose: 2 months of age.

  • Second Dose: 4 months of age.

  • Third Dose: 6 months of age (if needed).

The first dose may be given as early as 6 weeks of age, and should be given by age 14 weeks 6 days. The last dose should be given by 8 months of age.

Rotavirus vaccine may be given at the same time as other childhood vaccines.

SOME PEOPLE SHOULD NOT GET ROTAVIRUS VACCINE OR SHOULD WAIT

  • An infant who has had a severe (life-threatening) allergic reaction to a dose of rotavirus vaccine should not get another dose. An infant who has a severe (life-threatening) allergy to any component of rotavirus vaccine should not get the vaccine. Tell your caregiver if your infant has any severe allergies that you know of, including a severe allergy to latex.

  • Infants with "severe combined immunodeficiency" (SCID) should not get rotavirus vaccine.

  • Infants with mild illnesses can usually get the vaccine. Infants who are moderately or severely ill should probably wait until they recover. This includes infants who have moderate or severe diarrhea or vomiting. Ask your caregiver or nurse.

  • Check with your caregiver if your infant's immune system is weakened because of:

  • HIV, AIDS, or any other disease that affects the immune system.

  • Treatment with drugs such as long-term steroids.

  • Cancer or cancer treatment with radiation or drugs.

  • Tell your caregiver if your infant has ever had intussusception, a type of bowel blockage that is treated in a hospital.

WHAT ARE THE RISKS FROM ROTAVIRUS VACCINE?

  • A vaccine, like any medicine, could possibly cause serious problems, such as severe allergic reactions. The risk of any vaccine causing serious harm, or death, is extremely small.

  • A virus (or parts of a virus) called porcine circovirus is present in both rotavirus vaccines. These is no evidence that this virus is a safety risk or causes illness in humans. For more information, visit http://www.cdc.gov/vaccines/vpd-vac/rotavirus

  • Most infants who get rotavirus vaccine do not have any problems with it.

Mild problems

  • Infants might become irritable, or have mild, temporary diarrhea or vomiting after getting a dose of rotavirus vaccine.

Serious problems

  • Some studies have shown a small increase in cases of intussusception within a week after the first dose of rotavirus vaccine. Intussusception is a type of bowel blockage that is treated in a hospital. In some cases, surgery might be required. the estimated risk is 1 intussusception case per 100,000 infants.

WHAT IF THERE IS A MODERATE OR SEVERE REACTION?

What should I look for?

During the first week after the first dose of vaccine, look for episodes of stomach pain with severe crying (which may be brief), several episodes of vomiting, or blood in the stool. Your infant could act weak or be very irritable.

Look for any unusual condition, such as a severe allergic reaction or a high fever. If a severe allergic reaction occurred, it would be within a few minutes to an hour after the vaccination. Signs of a serious allergic reaction can include difficulty breathing, weakness, hoarseness or wheezing, a fast heartbeat, hives, dizziness, paleness, or swelling of the throat.

What should I do?

  • Call your caregiver or get the person to a caregiver right away.

  • Tell the caregiver what happened, the date and time it happened, and when the vaccination was given.

  • Ask the caregiver to report the reaction by filing a Vaccine Adverse Event Reporting System (VAERS) form. Or, you can file this report through the VAERS website at www.vaers.hhs.gov or by calling 1-800-822-7967.

VAERS does not provide medical advice.

THE NATIONAL VACCINE INJURY COMPENSATION PROGRAM

The National Vaccine Injury Compensation Program (VICP) was created in 1986.

Persons who believe they may have been injured by a vaccine may file a claim with VICP by calling 1-800-338-2382 or by visiting their website at www.hrsa.gov/vaccinecompensation.

HOW CAN I LEARN MORE?

  • Ask your caregiver. He or she can give you the vaccine package insert or suggest other sources of information.

  • Call your local or state health department.

  • Contact the Centers for Disease Control and Prevention (CDC):

  • Call 1-800-232-4636 (1-800-CDC-INFO).

  • Visit the CDC National Immunization Program website at www.cdc.gov/vaccines.

CDC Rotavirus Vaccine VIS (12/6/10)