Sotos Syndrome

Sotos syndrome is a rare genetic disorder. It causes excessive physical growth during the first 2 to 3 years of life. Most cases of Sotos syndrome occur sporadically. Familial cases have also been reported.


Children with Sotos syndrome tend to be large at birth. They are often taller, heavier, and have larger heads (macrocrania) than what is normal for their age.

Symptoms of the disorder vary from person to person. They may include:

  • Large and long head with a slightly protrusive forehead.

  • Large hands and feet.

  • Large distance between the eyes (hypertelorism).

  • Downslanting eyes.

  • Clumsiness.

  • Awkward gait.

  • Unusual aggressiveness or irritability.

These conditions may go along with the disorder:

  • Mild mental retardation.

  • Delayed motor, cognitive, and social development.

  • Low muscle tone (hypotonia).

  • Speech impairments.


There is no standard course of treatment for this syndrome. Treatment is symptomatic.

Sotos syndrome is not a life-threatening disorder. Patients may have a normal life expectancy. The initial abnormalities of Sotos syndrome usually resolve as the growth rate becomes normal. This happens after the first few years of life. Developmental delays may improve in the school-age years. Coordination problems may last into adulthood.