Multifocal Motor Neuropathy

Multifocal motor neuropathy is a progressive muscle disorder characterized by asymmetrical muscle weakness. The disorder may be mistaken for other more serious disorders. Early diagnosis allows patients to begin recovery quickly.


Symptoms, which begin in the arms and hands (upper extremities), may include muscle weakness, atrophy, and cramping. Involuntary contractions or twitching of a group of muscles (fasciculations) may also occur.


Treatment for multifocal motor neuropathy varies. Some individuals experience only mild, modest symptoms and require no treatment. For others, treatment generally consists of intravenous immunoglobulin (IVIG) or cyclophosphamide. Improvement in muscle strength usually beings within 3 to 6 weeks after treatment is started. Most patients who receive treatment early experience little, if any, disability. However, there is evidence of slow progression over many years.