Methotrexate Treatment for an Ectopic Pregnancy

Care After

Refer to this sheet in the next few weeks. These instructions provide you with information on caring for yourself after your treatment. Your caregiver may also give you more specific instructions. Your treatment has been planned according to current medical practices, but problems sometimes occur. Call your caregiver if you have any problems or questions after your treatment.


After you have received the methotrexate medicine, you need to be careful of your activities and watch your condition for several weeks. Even with methotrexate, an ectopic pregnancy can begin to bleed without warning. It may take 1 week before your pregnancy hormone level starts to drop.

  • Keep all follow-up blood work appointments as directed by your caregiver. This is very important. Blood work is usually done in 4 to 7 days, and then at weekly visits until there is no pregnancy hormone detected.

  • Avoid traveling too far away from your caregiver.

  • Do not have sexual intercourse until your caregiver says it is safe to do so.

  • You may resume your usual diet.

  • Limit strenuous activity.

  • Do not take folic acid, prenatal vitamins, or other vitamins that contain folic acid.

  • Do not take aspirin, ibuprofen, or naproxen (nonsteroidal anti-inflammatory drugs, NSAIDs).

  • Do not drink alcohol.


  • You cannot control your nausea and vomiting.

  • You cannot control your diarrhea.

  • You have sores in your mouth and want treatment.

  • You need pain medicine for your abdominal pain.

  • You have a rash.

  • You are having a reaction to the medicine.


  • You experience increasing abdominal or pelvic pain.

  • You notice increased bleeding.

  • You feel lightheaded or you faint.

  • You have shortness of breath.

  • Your heart rate increases.

  • You have a cough.

  • You have chills.

  • You have a fever.


  • Understand these instructions.

  • Will watch your condition.

  • Will get help right away if you are not doing well or get worse.