Enoxaparin, Home Use

ExitCare ImageEnoxaparin (Lovenox®) injection is a medication used to prevent clots from developing in your veins. Medications such as enoxaparin are called blood thinners or anticoagulants. If blood clots are untreated they could travel to your lungs. This is called a pulmonary embolus. A blood clot in your lungs can be fatal.

Caregivers often use anticoagulants such as enoxaparin to prevent clots following surgery. It is also used along with aspirin when the heart is not getting enough blood.

Continue the enoxaparin injections as directed by your caregiver. Your caregiver will use blood clotting test results to decide when you can safely stop using enoxaparin injections. If your caregiver prescribes any additional anticoagulant, you must take it exactly as directed.


  • If you have received recent epidural anesthesia, spinal anesthesia, or a spinal tap while receiving anticoagulants, you are at risk for developing a blood clot in or around the spine. This condition could result in long-term or permanent paralysis.

  • Because anticoagulants thin your blood, severe bleeding may occur from any tissue or organ. Symptoms of the blood being too thin may include:

  • Bleeding from the nose or gums that does not stop quickly.

  • Unusual bruising or bruising easily.

  • Swelling or pain at an injection site.

  • A cut that does not stop bleeding within 10 minutes.

  • Continual nausea for more than 1 day or vomiting blood.

  • Coughing up blood.

  • Blood in the urine which may appear as pink, red, or brown urine.

  • Blood in bowel movements which may appear as red, dark or black stools.

  • Sudden weakness or numbness of the face, arm, or leg, especially on one side of the body.

  • Sudden confusion.

  • Trouble speaking (aphasia) or understanding.

  • Sudden trouble seeing in one or both eyes.

  • Sudden trouble walking.

  • Dizziness.

  • Loss of balance or coordination.

  • Severe pain, such as a headache, joint pain, or back pain.

  • Fever.

  • Bruising around the injection sites may be expected.

  • Platelet drops, known as "thrombocytopenia," can occur with enoxaparin use. A condition called "heparin-induced thrombocytopenia" has been seen. If you have had this condition, you should tell your caregiver. Your caregiver may direct you to have blood tests to monitor this condition.

  • Do not use if you have allergies to the medication, heparin, or pork products.

  • Other side effects may include mild local reactions or irritation at the site of injection, pain, bruising, and redness of skin.


You will be instructed by your caregiver how to give enoxaparin injections.

  1. Before giving your medication you should make sure the injection is a clear and colorless or pale yellow solution. If your medication becomes discolored or has particles in the bottle, do not use and notify your caregiver.

  2. When using the 30 and 40 mg pre-filled syringes, do not expel the air bubble from the syringe before the injection. This makes sure you use all the medication in the syringe.

  3. The injections will be given subcutaneously. This means it is given into the fat over the belly (abdomen). It is given deep beneath the skin but not into the muscle. The shots should be injected around the abdominal wall. Change the sites of injection each time. The whole length of the needle should be introduced into a skin fold held between the thumb and forefinger; the skin fold should be held throughout the injection. Do not rub the injection site after completion of the injection. This increases bruising. Enoxaparin injection pre-filled syringes and graduated pre-filled syringes are available with a system that shields the needle after injection.

  4. Inject by pushing the plunger to the bottom of the syringe.

  5. Remove the syringe from the injection site keeping your finger on the plunger rod. Be careful not to stick yourself or others.

  6. After injection and the syringe is empty, set off the safety system by firmly pushing the plunger rod. The protective sleeve will automatically cover the needle and you can hear a click. The click means your needle is safely covered. Do not try replacing the needle shield.

  7. Get rid of the syringe in the nearest sharps container.

  8. Keep your medication safely stored at room temperatures.

  • Due to the complications of anticoagulants, it is very important that you take your anticoagulant as directed by your caregiver. Anticoagulants need to be taken exactly as instructed. Be sure you understand all your anticoagulant instructions.

  • Changes in medicines, supplements, diet, and illness can affect your anticoagulation therapy. Be sure to inform your caregivers of any of these changes.

  • While on anticoagulants, you will need to have blood tests done routinely as directed by your caregivers.

  • Be careful not to cut yourself when using sharp objects.

  • Limit physical activities or sports that could result in a fall or cause injury.

  • It is extremely important that you tell all of your caregivers and dentist that you are taking an anticoagulant, especially if you are injured or plan to have any type of procedure or operation.

  • Follow up with your laboratory test and caregiver appointments as directed. It is very important to keep your appointments. Not keeping appointments could result in a chronic or permanent injury, pain, or disability.


  • You develop any rashes.

  • You have any worsening of the condition for which you are receiving anticoagulation therapy.


  • Bleeding from the nose or gums does not stop quickly.

  • You have unusual bruising or are bruising easily.

  • Swelling or pain occurs at an injection site.

  • A cut does not stop bleeding within 10 minutes.

  • You have continual nausea for more than 1 day or are vomiting blood.

  • You are coughing up blood.

  • You have blood in the urine.

  • You have dark or black stools.

  • You have sudden weakness or numbness of the face, arm, or leg, especially on one side of the body.

  • You have sudden confusion.

  • You have trouble speaking (aphasia) or understanding.

  • You have sudden trouble seeing in one or both eyes.

  • You have sudden trouble walking.

  • You have dizziness.

  • You have a loss of balance or coordination.

  • You have severe pain, such as a headache, joint pain, or back pain.

  • You have a serious fall or head injury, even if you are not bleeding.

  • You have an oral temperature above 102° F (38.9° C), not controlled by medicine.

ANY OF THESE SYMPTOMS MAY REPRESENT A SERIOUS PROBLEM THAT IS AN EMERGENCY. Do not wait to see if the symptoms will go away. Get medical help right away. Call your local emergency services (911 in U.S.). DO NOT drive yourself to the hospital.


  • Understand these instructions.

  • Will watch your condition.

  • Will get help right away if you are not doing well or get worse.