Endometrial Biopsy

Endometrial biopsy is a procedure in which a tissue sample is taken from inside the uterus. The tissue sample is then looked at under a microscope to see if the tissue is normal or abnormal. The endometrium is the lining of the uterus. This procedure helps determine where you are in your menstrual cycle and how hormone levels are affecting the lining of the uterus. This procedure may also be used to evaluate uterine bleeding or to diagnose endometrial cancer, tuberculosis, polyps, or inflammatory conditions.


  • Any allergies you have.

  • All medicines you are taking, including vitamins, herbs, eye drops, creams, and over-the-counter medicines.

  • Previous problems you or members of your family have had with the use of anesthetics.

  • Any blood disorders you have.

  • Previous surgeries you have had.

  • Medical conditions you have.

  • Possibility of pregnancy.


Generally, this is a safe procedure. However, as with any procedure, complications can occur. Possible complications include:

  • Bleeding.

  • Pelvic infection.

  • Puncture of the uterine wall with the biopsy device (rare).


  • Keep a record of your menstrual cycles as directed by your health care provider. You may need to schedule your procedure for a specific time in your cycle.

  • You may want to bring a sanitary pad to wear home after the procedure.

  • Arrange for someone to drive you home after the procedure if you will be given a medicine to help you relax (sedative). 


  • You may be given a sedative to relax you.

  • You will lie on an exam table with your feet and legs supported as in a pelvic exam.

  • Your health care provider will insert an instrument (speculum) into your vagina to see your cervix.

  • Your cervix will be cleansed with an antiseptic solution. A medicine (local anesthetic) will be used to numb the cervix.

  • A forceps instrument (tenaculum) will be used to hold your cervix steady for the biopsy.

  • A thin, rodlike instrument (uterine sound) will be inserted through your cervix to determine the length of your uterus and the location where the biopsy sample will be removed.

  • A thin, flexible tube (catheter) will be inserted through your cervix and into the uterus. The catheter is used to collect the biopsy sample from your endometrial tissue.

  • The catheter and speculum will then be removed, and the tissue sample will be sent to a lab for examination.


  • You will rest in a recovery area until you are ready to go home.

  • You may have mild cramping and a small amount of vaginal bleeding for a few days after the procedure. This is normal.

  • Make sure you find out how to get your test results.