Clostridium Difficile Infection

ExitCare Image Clostridium difficile (C. dif ficile) is a bacteria found in the intestinal tract or colon. Under certain conditions, it causes diarrhea and sometimes severe disease. The severe form of the disease is known as pseudomembranous colitis (often called C. dif ficile colitis). This disease can damage the lining of the colon or cause the colon to become enlarged (toxic megacolon).


Your colon normally contains many different bacteria, including C. dif ficile. The balance of bacteria in your colon can change during illness. This is especially true when you take antibiotic medicine. Taking antibiotics may allow the C. dif ficile to grow, multiply excessively, and make a toxin that then causes illness. The elderly and people with certain medical conditions have a greater risk of getting C. dif ficile infections.


  • Watery diarrhea.

  • Fever.

  • Fatigue.

  • Loss of appetite.

  • Nausea.

  • Abdominal swelling, pain, or tenderness.

  • Dehydration.


Your symptoms may make your caregiver suspicious of a C. dif ficile infection, especially if you have used antibiotics in the preceding weeks. However, there are only 2 ways to know for certain whether you have a C. dif ficile infection:

  • A lab test that finds the toxin in your stool.

  • The specific appearance of an abnormality (pseudomembrane) in your colon. This can only be seen by doing a sigmoidoscopy or colonoscopy. These procedures involve passing an instrument through your rectum to look at the inside of your colon.

Your caregiver will help determine if these tests are necessary.


  • Most people are successfully treated with one of two specific antibiotics, usually given by mouth. Other antibiotics you are receiving are stopped if possible.

  • Intravenous (IV) fluids and correction of electrolyte imbalance may be necessary.

  • Rarely, surgery may be needed to remove the infected part of the intestines.

  • Careful hand washing by you and your caregivers is important to prevent the spread of infection. In the hospital, your caregivers may also put on gowns and gloves to prevent the spread of the C. dif ficile bacteria. Your room is also cleaned regularly with a solution containing bleach or a product that is known to kill C. dif ficile.


  • Drink enough fluids to keep your urine clear or pale yellow. Avoid milk, caffeine, and alcohol.

  • Ask your caregiver for specific rehydration instructions.

  • Try eating small, frequent meals rather than large meals.

  • Take your antibiotics as directed. Finish them even if you start to feel better.

  • Do not use medicines to slow diarrhea. This could delay healing or cause complications.

  • Wash your hands thoroughly after using the bathroom and before preparing food.

  • Make sure people who live with you wash their hands often, too.

  • Carefully disinfect all surfaces with a product that contains chlorine bleach.


  • Diarrhea persists longer than expected or recurs after completing your course of antibiotic treatment for the C. dif ficile infection.

  • You have trouble staying hydrated.


  • You develop a new fever.

  • You have increasing abdominal pain or tenderness.

  • There is blood in your stools, or your stools are dark black and tarry.

  • You cannot hold down food or liquids.


  • Understand these instructions.

  • Will watch your condition.

  • Will get help right away if you are not doing well or get worse.