Apolipoprotein E Genotyping

This is a test used to check for an inherited component to atherosclerosis. This means it checks your DNA or genetic likelihood of having premature hardening of your arteries. It is also used to help make treatment decisions in individuals with cardiovascular disease. It is used as an aid in the diagnosis of probable late onset Alzheimer's disease in a symptomatic adult, or to help confirm a diagnosis of Type 3 hyperlipoproteinemia (also known as familial dysbetalipoproteinemia).

If your doctor suspects that you have an inherited component to your high cholesterol and triglyceride levels or if you have xanthomas (yellowish lesions) on your skin, if you have progressive symptoms of dementia and your doctor wants to determine the likelihood that this is due to Alzheimer's disease.

PREPARATION FOR TEST

A blood sample drawn from a vein in your arm.

NORMAL FINDINGS

ApoE e3 has "normal" lipid metabolism, thus no genotype impact. If you do not have e4 alleles and your ApoE test is negative, you will have no likelihood of developing premature atherosclerosis.

Ranges for normal findings may vary among different laboratories and hospitals. You should always check with your doctor after having lab work or other tests done to discuss the meaning of your test results and whether your values are considered within normal limits.

MEANING OF TEST

Your caregiver will go over the test results with you and discuss the importance and meaning of your results, as well as treatment options and the need for additional tests if necessary.

OBTAINING THE TEST RESULTS

It is your responsibility to obtain your test results. Ask the lab or department performing the test when and how you will get your results.